The Humanis Policlub was formed in 2023 as a fledgling loosely-allied organization of anti-metahuman, anti-Amerind human supremacists, during the same year that the US Supreme Court granted equal rights to all metahuman races. By 2046, when the policlub idea spread across North America, it had a major following as one of the strongest and most well-organized anti-metahuman policlubs in existence. In 2057, the Humanis Policlub heavily backed the campaign of Kenneth Brackhaven (the nephew of Karl Brackhaven, the leader of the Seattle Humanis chapter) under the Archconservative party for UCAS president. During the Year of the Comet and the wave of SURGE, the Humanis Policlub tapped into conservative fundamentalist Christian organizations by creating the Cult of the Seventh Seal, based around the SURGE expression of Jeremiah Adams and the apocalyptic vision of Revelations.
There have been numerous allegations that the Humanis Policlub is in fact a public arm of terrorist groups such as Alamos 20,000 (probably true) and Human Nation (probably false). In response, the Humanis Policlub has "softened" its image as a pro-human group rather than a rabidly anti-metahuman hate group. It extends its major influence through politics and lobbying, although it still makes headlines when engaging in anti-metahuman violence. Often, Humanis makes appeals to "traditional conservative family values" and "pro-human legislation" and denounce metahumans as "mutations" or "sub-species". While there are other splinter policlubs with similar messages such as the Unity Coalition, the Humanis Policlub remains the loudest and strongest of them all, with chapterhouses all over the UCAS and CAS.