Jake Armitage was a courier who was shot by assassins and left for dead in 2050 in Seattle. However his life was saved by a shapeshifting lupine figure named Kitsume. He awoke in a morgue with amnesia.
Trying to piece together his memories and determine who wanted him dead, he began to work as a shadowrunner. Jake is a rare shaman with cyberware, because he had it implanted before discovering his calling as a Dog Shaman.
He discovered that his head not only contained a bomb, but also crucial data he carried as a courier without his knowledge. This data was a program designed to kill a malevolent artificial intelligence created and protected by Drake and Aneki Corporation.
In 2054, he assisted a fellow shadowrunner in investigating the Ripper killings in Seattle.
As a side effect of Jake Armitage's confrontation with this artificial intelligence a copy of his personality accidentally was uploaded into the matrix. - This copied personality became one of an unknown number of e-ghost fragments, that took possession of the FBI agent Seth Dietrich in 2075. 
While the plot of the video game he appeared in was loosely adapted from Robert Charrette's novel Never Deal With a Dragon, the name "Armitage" is a reference to a character from William Gibson's novel, Neuromancer; written in 1981 and possibly the most influential book in the Cyberpunk genre. However, Jake Armitage more closely resembles the main protagonist in Neuromancer: Henry Case.